Destrehan is a census-designated place in St. Charles Parish, Louisiana, United States. The population was 11,535 at the 2010 census, an increase of 275 over the 2000 tabulation of 11,260.The community is named after Jean Noël Destréhan, who was twice President of the Orleans Territory's legislative council during his service there in 1806 and 1811. He was elected to the United States Senate when Louisiana became a state in 1812, but he resigned after a month. He served in the Louisiana State Senate from 1812 to 1817.Destrehan Plantation, his former home, is listed on the National Register of Historic Places. The main house has been restored and is one of the attractions on the Great River Road along the Mississippi River.